Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice

Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice

Abstract Diabetic nephropathy (DN) is associated with albuminuria and loss of kidney function and is the leading cause of end‐stage renal disease. Despite evidence of sex‐associated differences in the progression of DN in human patients, male mice are predominantly being used in preclinical DN resea...

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Bibliographic Details
Main Authors: Frederikke E. Sembach, Lisbeth N. Fink, Thea Johansen, Brandon B. Boland, Thomas Secher, Sebastian T. Thrane, Jens C. Nielsen, Keld Fosgerau, Niels Vrang, Jacob Jelsing, Tanja X. Pedersen, Mette V. Østergaard
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Physiological Reports
Subjects:
albuminuria
animal model
diabetic nephropathy
mesangial expansion
uninephrectomy
Online Access:https://doi.org/10.14814/phy2.14333

Internet

https://doi.org/10.14814/phy2.14333

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