Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
There is interest in developing long-lasting local anaesthetics for a range of applications. Here, the authors report on the application of tetrodotoxin conjugated to amphiphilic biodegradable polymer to reduce systemic toxicity, achieve sustained release and investigate application as a local anaes...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10296-9 |