PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model

PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model

BackgroundPrevious studies have proved that peripheral nerve injury is involved in the pathogenesis of neuropathic pain (NP). The peripheral nerve injury primes spinal M1 microglia phenotype and produces pro-inflammatory cytokines, which are responsible for neurotoxic and neuronal hyper-excitable ou...

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Bibliographic Details
Main Authors: Xilei Li, Qulian Guo, Zhi Ye, E. Wang, Wangyuan Zou, Zhihua Sun, Zhenghua He, Tao Zhong, Yingqi Weng, Yundan Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
PPAR γ
microglia
neuropathic pain
CX3CR1
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.620525/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.620525/full

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