The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation
Cas5 is a transcriptional regulator of responses to cell wall stress in the fungal pathogen Candida albicans. Here, Xie et al. show that Cas5 also modulates cell cycle dynamics and responses to antifungal drugs.
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Nature Publishing Group
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00547-y |
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doaj-ffb813afe4d54f829962b3863b93dbc32021-05-11T07:30:33ZengNature Publishing GroupNature Communications2041-17232017-09-018111810.1038/s41467-017-00547-yThe Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulationJinglin L. Xie0Longguang Qin1Zhengqiang Miao2Ben T. Grys3Jacinto De La Cruz Diaz4Kenneth Ting5Jonathan R. Krieger6Jiefei Tong7Kaeling Tan8Michelle D. Leach9Troy Ketela10Michael F. Moran11Damian J. Krysan12Charles Boone13Brenda J. Andrews14Anna Selmecki15Koon Ho Wong16Nicole Robbins17Leah E. Cowen18Department of Molecular Genetics, University of TorontoFaculty of Health Sciences, University of MacauFaculty of Health Sciences, University of MacauDepartment of Molecular Genetics, University of TorontoDepartment of Microbiology and Immunology, University of RochesterDepartment of Molecular Genetics, University of TorontoThe Hospital for Sick Children, SPARC BiocentreThe Hospital for Sick Children, Program in Cell Biology, Peter Gilgan Centre for Research and LearningFaculty of Health Sciences, University of MacauDepartment of Molecular Genetics, University of TorontoDepartment of Molecular Genetics, University of TorontoDepartment of Molecular Genetics, University of TorontoDepartment of Microbiology and Immunology, University of RochesterDepartment of Molecular Genetics, University of TorontoDepartment of Molecular Genetics, University of TorontoDepartment of Medical Microbiology and Immunology, Creighton University School of MedicineFaculty of Health Sciences, University of MacauDepartment of Molecular Genetics, University of TorontoDepartment of Molecular Genetics, University of TorontoCas5 is a transcriptional regulator of responses to cell wall stress in the fungal pathogen Candida albicans. Here, Xie et al. show that Cas5 also modulates cell cycle dynamics and responses to antifungal drugs.https://doi.org/10.1038/s41467-017-00547-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jinglin L. Xie Longguang Qin Zhengqiang Miao Ben T. Grys Jacinto De La Cruz Diaz Kenneth Ting Jonathan R. Krieger Jiefei Tong Kaeling Tan Michelle D. Leach Troy Ketela Michael F. Moran Damian J. Krysan Charles Boone Brenda J. Andrews Anna Selmecki Koon Ho Wong Nicole Robbins Leah E. Cowen |
| spellingShingle |
Jinglin L. Xie Longguang Qin Zhengqiang Miao Ben T. Grys Jacinto De La Cruz Diaz Kenneth Ting Jonathan R. Krieger Jiefei Tong Kaeling Tan Michelle D. Leach Troy Ketela Michael F. Moran Damian J. Krysan Charles Boone Brenda J. Andrews Anna Selmecki Koon Ho Wong Nicole Robbins Leah E. Cowen The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation Nature Communications |
| author_facet |
Jinglin L. Xie Longguang Qin Zhengqiang Miao Ben T. Grys Jacinto De La Cruz Diaz Kenneth Ting Jonathan R. Krieger Jiefei Tong Kaeling Tan Michelle D. Leach Troy Ketela Michael F. Moran Damian J. Krysan Charles Boone Brenda J. Andrews Anna Selmecki Koon Ho Wong Nicole Robbins Leah E. Cowen |
| author_sort |
Jinglin L. Xie |
| title |
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation |
| title_short |
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation |
| title_full |
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation |
| title_fullStr |
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation |
| title_full_unstemmed |
The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation |
| title_sort |
candida albicans transcription factor cas5 couples stress responses, drug resistance and cell cycle regulation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-09-01 |
| description |
Cas5 is a transcriptional regulator of responses to cell wall stress in the fungal pathogen Candida albicans. Here, Xie et al. show that Cas5 also modulates cell cycle dynamics and responses to antifungal drugs. |
| url |
https://doi.org/10.1038/s41467-017-00547-y |
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