Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

Abstract Background To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) development. Methods Ten-week-old male C57BL/6 mice were randomized a...

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Bibliographic Details
Main Authors: Jiansen Lu, Hongbo Zhang, Jianying Pan, Zhiqiang Hu, Liangliang Liu, Yanli Liu, Xiao Yu, Xiaochun Bai, Daozhang Cai, Haiyan Zhang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Fargesin
Macrophage
Mitogen-activated protein kinase pathway
Nuclear factor kappa-B pathway
Online Access:https://doi.org/10.1186/s13075-021-02512-z

Internet

https://doi.org/10.1186/s13075-021-02512-z

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