Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as inclusion bodies in the brain and spinal cord of patients with the motor neuron diseases: amyotrophic lateral sclerosis (ALS) a...

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Bibliographic Details
Main Authors: Archana Prasad, Vidhya Bharathi, Vishwanath Sivalingam, Amandeep Girdhar, Basant K. Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyotrophic lateral sclerosis (ALS)
TDP-43
mitotoxicity
liquid-liquid phase separation (LLPS)
endocytosis
frontotemporal lobar degeneration (FTLD)
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00025/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00025/full

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