Phase-1 bioactivation mechanisms of aflatoxin through AhR, CAR and PXR nuclear receptors and the interactions with Nigella sativa seeds and thymoquinone in broilers

Phase-1 bioactivation mechanisms of aflatoxin through AhR, CAR and PXR nuclear receptors and the interactions with Nigella sativa seeds and thymoquinone in broilers

Aflatoxins (AFs) are metabolised in two main phases in the liver. Cytochrome p450 enzyme (CYP) 1A1 and CYP2A6 are expressed through AhR, CAR and PXR nuclear receptors in phase-1 biotransformation of AFs. This study is the first to examine phase-1 biotransformation mechanisms of AF and the activity o...

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Bibliographic Details
Main Authors: Mehmet Burak Ates, Mustafa Ortatatli
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Aflatoxin
PXR
AhR
CAR
Immunohistochemistry
CYP450s
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320316109

Internet

http://www.sciencedirect.com/science/article/pii/S0147651320316109

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