T-Cell Proapoptotic and Antifibrotic Activity Against Autologous Skin Fibroblasts in vitro Is Associated With IL-17A Axis Upregulation in Systemic Sclerosis

T-Cell Proapoptotic and Antifibrotic Activity Against Autologous Skin Fibroblasts in vitro Is Associated With IL-17A Axis Upregulation in Systemic Sclerosis

Background: Systemic sclerosis (SSc) T cells can induce apoptosis of autologous skin fibroblasts in vitro. Th17 cells have been reported to increase in SSc patients, and interleukin-17A (IL-17A) has a profibrotic function. We used a system based on T-cell-autologous fibroblast co-cultures to further...

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Bibliographic Details
Main Authors: Serena Vettori, Giusi Barra, Barbara Russo, Alessia Borgia, Giuseppe Pasquale, Luciana Pellecchia, Lucia Vicedomini, Raffaele De Palma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis
T cells
fibroblasts
co-cultures
apoptosis
IL-17A
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00220/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00220/full

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