Transitional B Cells and TLR9 Responses Are Defective in Selective IgA Deficiency

Selective IgA deficiency (IgAD) is the most common primary antibody deficiency in the western world with affected individuals suffering from an increased burden of autoimmunity, atopic diseases and infections. It has been shown that IgAD B cells can be induced with germinal center mimicking reaction...

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Bibliographic Details
Main Authors: Andri L. Lemarquis, Helga K. Einarsdottir, Rakel N. Kristjansdottir, Ingileif Jonsdottir, Bjorn R. Ludviksson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
IgA
CpG
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00909/full