Double Spirocyclization of Arylidene-Δ<sup>2</sup>-Pyrrolin-4-Ones with 3-Isothiocyanato Oxindoles

Double Spirocyclization of Arylidene-Δ<sup>2</sup>-Pyrrolin-4-Ones with 3-Isothiocyanato Oxindoles

Arilidene-Δ<sup>2</sup>-pyrrolin-4-ones undergo organocatalyzed double spirocyclization with 3-isothiocianato oxindoles in a domino 1,4/1,2-addition sequence. The products contain three contiguous stereocenters (<i>ee</i> up to 98%, <i>dr</i> up to 99:1, 12 exampl...

Full description

Bibliographic Details
Main Authors: Sebastijan Ričko, Žan Testen, Luka Ciber, Franc Požgan, Bogdan Štefane, Helena Brodnik, Jurij Svete, Uroš Grošelj
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Catalysts
Subjects:
organocatalysis
pyrrolones
spiroheterocyclization
3-isothiocyanato oxindoles
cascade reaction
spiro compounds
Online Access:https://www.mdpi.com/2073-4344/10/10/1211

Internet

https://www.mdpi.com/2073-4344/10/10/1211

Similar Items