G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells

G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells

Abstract Background Glioblastoma is the most aggressive and most lethal primary brain tumor in the adulthood. Current standard therapies are not curative and novel therapeutic options are urgently required. Present knowledge suggests that the continued glioblastoma growth and recurrence is determine...

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Bibliographic Details
Main Authors: F. Berardinelli, M. Tanori, D. Muoio, M. Buccarelli, A. di Masi, S. Leone, L. Ricci-Vitiani, R. Pallini, M. Mancuso, A. Antoccia
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
G4 ligands
RHPS4
Telomeres
Radiosensitization
Glioma stem-like cells
Online Access:http://link.springer.com/article/10.1186/s13046-019-1293-x

Internet

http://link.springer.com/article/10.1186/s13046-019-1293-x

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