The glucuronide metabolites of kaempferol and quercetin, targeting to the AKT PH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism

The glucuronide metabolites of kaempferol and quercetin, targeting to the AKT PH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism

Kaempferol and quercetin, as dietary flavonoids, are beneficial to diabetes risk reduction. Clarifying the mechanism of dietary flavonoids in improving glucose metabolism may meet the functional and nutritional requirements. In this paper, PCA revealed two glucuronides, kaempferol-3-glucuronide (K-3...

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Bibliographic Details
Main Authors: Ge Fang, Chuanjing Cheng, Manqian Zhang, Xiaoyao Ma, Shengnan Yang, Xiaotao Hou, Jiagang Deng, Yuanyuan Hou, Gang Bai
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Functional Foods
Subjects:
Kaempferol-3-glucuronide
Quercetin-3-glucuronide
Glucose metabolism
AKT
PH domain
Online Access:http://www.sciencedirect.com/science/article/pii/S175646462100150X

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http://www.sciencedirect.com/science/article/pii/S175646462100150X

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