Apoptosis in Cancer Cells Is Induced by Alternative Splicing of hnRNPA2/B1 Through Splicing of Bcl-x, a Mechanism that Can Be Stimulated by an Extract of the South African Medicinal Plant, Cotyledon orbiculata

Apoptosis in Cancer Cells Is Induced by Alternative Splicing of hnRNPA2/B1 Through Splicing of Bcl-x, a Mechanism that Can Be Stimulated by an Extract of the South African Medicinal Plant, Cotyledon orbiculata

Alternative splicing is deregulated in cancer and alternatively spliced products can be linked to cancer hallmarks. Targeting alternative splicing could offer novel effective cancer treatments. We investigated the effects of the crude extract of a South African medicinal plant, Cotyledon orbiculata,...

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Bibliographic Details
Main Authors: Tshepiso Jan Makhafola, Mzwandile Mbele, Kiren Yacqub-Usman, Amy Hendren, Daisy Belle Haigh, Zoe Blackley, Mervin Meyer, Nigel Patrick Mongan, David Owen Bates, Zodwa Dlamini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
esophageal cancer
Cotyledon orbiculata
hnRNPA2B1
Bcl-x
caspase-3
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.547392/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.547392/full

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