Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach

Use of a neuron-glia genome-scale metabolic reconstruction to model the metabolic consequences of the Arylsulphatase a deficiency through a systems biology approach

Metachromatic leukodystrophy (MLD) is a human neurodegenerative disorder characterized by progressive damage on the myelin band in the nervous system. MLD is caused by the impaired function of the lysosomal enzyme Arylsulphatase A (ARSA). The physiopathology mechanisms and the biochemical consequenc...

Full description

Bibliographic Details
Main Authors: Olga Y. Echeverri-Peña, Diego A. Salazar-Barreto, Alexander Rodríguez-Lopez, Janneth González, Carlos J. Alméciga-Díaz, Cristian H. Verano-Guevara, Luis A. Barrera
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Heliyon
Subjects:
Metachromatic leukodystrophy
System biology
Arylsulphatase A
Myelin sheath
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021017746

Internet

http://www.sciencedirect.com/science/article/pii/S2405844021017746

Similar Items