Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores

Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores

Faithful chromosome segregation during mitosis is crucial for maintaining genome stability. The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate mitotic progression. Defective SAC signaling leads to premature sister chromatid separation and aneuploid daughter cells...

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Bibliographic Details
Main Authors: Zhen Dou, Diogjena Katerina Prifti, Ping Gui, Xing Liu, Sabine Elowe, Xuebiao Yao
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
spindle assembly checkpoint (SAC)
kinetochore
microtubule
kinase
localization
Online Access:https://www.mdpi.com/2073-4409/8/3/278

Internet

https://www.mdpi.com/2073-4409/8/3/278

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