A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization.

A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization.

Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. The venom contains several enzymatic toxins. Herein, we describe the cloning, expression, refolding an...

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Bibliographic Details
Main Authors: Valéria Pereira Ferrer, Thiago Lopes de Mari, Luiza Helena Gremski, Dilza Trevisan Silva, Rafael Bertoni da Silveira, Waldemiro Gremski, Olga Meiri Chaim, Andrea Senff-Ribeiro, Helena Bonciani Nader, Silvio Sanches Veiga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3642055?pdf=render

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http://europepmc.org/articles/PMC3642055?pdf=render

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