Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis

Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with few effective therapeutic options. Structural remodelling of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes (LOX, LOXL1-4)] might contribute to disease p...

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Bibliographic Details
Main Authors: Gavin Tjin, Eric S. White, Alen Faiz, Delphine Sicard, Daniel J. Tschumperlin, Annabelle Mahar, Eleanor P. W. Kable, Janette K. Burgess
Format: Article
Language:English
Published: The Company of Biologists 2017-11-01
Series:Disease Models & Mechanisms
Subjects:
Idiopathic pulmonary fibrosis
Extracellular matrix
Collagen
Lysyl oxidase
Second harmonic generation
Online Access:http://dmm.biologists.org/content/10/11/1301

Internet

http://dmm.biologists.org/content/10/11/1301

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