Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products

Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products

Many fungal quinazolinone metabolites, which contain the methyl-indole pyrazino [1,2-b]quinazoline-3,6-dione core, have been found to possess promising antitumor activity. The purpose of this work was to synthesize the enantiomeric pairs of two members of this quinazolinone family, to explore their...

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Bibliographic Details
Main Authors: Solida Long, Diana I. S. P. Resende, Anake Kijjoa, Artur M. S. Silva, André Pina, Tamara Fernández-Marcelo, M. Helena Vasconcelos, Emília Sousa, Madalena M. M. Pinto
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Marine Drugs
Subjects:
antitumor
enantiomers
fiscalins
quinazolinones
synthesis
Online Access:http://www.mdpi.com/1660-3397/16/8/261

Internet

http://www.mdpi.com/1660-3397/16/8/261

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