Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis

Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis

Background/Aims: Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various cell functions including cell growth and death. It is produced by two sphingosine kinases (SK) denoted as SK-1 and SK-2. Whereas SK-1 has been extensively studied and has been appointed a role in promot...

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Bibliographic Details
Main Authors: Sandra Beyer, Stephanie Schwalm, Josef Pfeilschifter, Andrea Huwiler
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Mesangial cells
Proliferation
Apoptosis
Autophagy
S1P
Transgenic SK-2 mice
Online Access:https://www.karger.com/Article/FullText/491625

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https://www.karger.com/Article/FullText/491625

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