Therapeutic Effect of Calcimimetics on Osteoclast–Osteoblast Crosslink in Chronic Kidney Disease and Mineral Bone Disease

Therapeutic Effect of Calcimimetics on Osteoclast–Osteoblast Crosslink in Chronic Kidney Disease and Mineral Bone Disease

We have previously demonstrated calcimimetics optimize the balance between osteoclastic bone resorption and osteoblastic mineralization through upregulating Wingless and int-1 (Wnt) signaling pathways in the mouse and cell model. Nonetheless, definitive human data are unavailable concerning therapeu...

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Bibliographic Details
Main Authors: Kuo-Chin Hung, Jia-Feng Chang, Yung-Ho Hsu, Chih-Yu Hsieh, Mai-Szu Wu, Mei-Yi Wu, I-Jen Chiu, Ren-Si Syu, Ting-Ming Wang, Chang-Chin Wu, Lie-Yee Hung, Cai-Mei Zheng, Kuo-Cheng Lu
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
chronic kidney disease-mineral bone disease
cinacalcet
wnt
bone mineral density
osteoclast–osteoblast interaction
sclerostin
Online Access:https://www.mdpi.com/1422-0067/21/22/8712

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https://www.mdpi.com/1422-0067/21/22/8712

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