M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

Abstract Background Osteoblast differentiation is a vital process for fracture healing, and exosomes are nanosized membrane vesicles that can deliver therapeutic drugs easily and safely. Macrophages participate in the regulation of various biological processes in vivo, and macrophage-derived exosome...

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Bibliographic Details
Main Authors: Yuan Xiong, Lang Chen, Chenchen Yan, Wu Zhou, Tao Yu, Yun Sun, Faqi Cao, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi, Guohui Liu
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Nanobiotechnology
Subjects:
Exosome
MiR-5106
Osteoblast
Fracture
SIK2
SIK3
Online Access:http://link.springer.com/article/10.1186/s12951-020-00622-5

Internet

http://link.springer.com/article/10.1186/s12951-020-00622-5

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