Design, synthesis and biological evaluation of aminoalkylated chalcones as antimalarial agent
Aminoalkylated chalcone compounds (4a-4c) have been designed using Quantitative Structure-Activity Relationship (QSAR) analysis, synthesized and evaluated for their in vitro antimalarial activity. The best QSAR model obtained was log IC50 = 705.132 (qC7) - 65.573 (qC3) - 24.845 (qC4) - 4.634 (qC13)...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia,
2020-11.
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| Online Access: | Get fulltext |