Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities

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A number of novel spiro-pyrrolidines/pyrrolizines derivatives were synthesized through [3+2]-cycloaddition of azomethine ylides with 3,5-bis[(E)- arylmethylidene]tetrahydro-4(1H)-pyridinones 2a-n. Azomethine ylides were generated in situ from the reaction of 1H-indole-2,3-dione (isatin, 3) with N-me...

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Bibliographic Details
Main Authors: Almansour, Abdulrahman I. (Author), Kumar, Raju Suresh (Author), Beevi, Farzana (Author), Shirazi, Amir Nasrolahi (Author), Osman, Hasnah (Author), Ismail, Rusli (Author), Tan, Soo Choon (Author), Brian, Sullivan (Author), Kellen, McCaffrey (Author), Nahhas, Alaa (Author), Parang, Keykavous (Author), Ali, Mohamed Ashraf (Author)
Format: Article
Language:English
Published: MDPI, 2014.
Subjects:
QD1-999 Chemistry
R735-854 Medical education. Medical schools. Research
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