Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice
Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease, providing compelling evidence that high blood choles...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The American Physiological Society,
2010.
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| Subjects: | |
| Online Access: | Get fulltext |