Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape

Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape

We describe protein interaction quantitation (PIQ), a computational method for modeling the magnitude and shape of genome-wide DNase I hypersensitivity profiles to identify transcription factor (TF) binding sites. Through the use of machine-learning techniques, PIQ identified binding sites for >7...

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Bibliographic Details
Main Authors: Lewis, Sophia (Author), van Hoff, John Peter (Author), Karun, Vivek (Author), Hashimoto, Tatsunori Benjamin (Contributor), Sherwood, Richard I. (Author), O'Donnell, Charles William (Contributor), Barkal, Amira A. (Author), Jaakkola, Tommi S. (Contributor), Gifford, David K. (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-12-14T02:21:40Z.
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