Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

Dysregulation of ErbB-family signaling underlies numerous pathologies and has been therapeutically targeted through inhibiting ErbB-receptors themselves or their cognate ligands. For the latter, "decoy" antibodies have been developed to sequester ligands including heparin-binding epidermal...

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Bibliographic Details
Main Authors: Miller, Miles Aaron (Contributor), Moss, Marcia L. (Author), Powell, Gary (Author), Petrovich, Robert (Author), Edwards, Lori (Author), Griffith, Linda G. (Contributor), Lauffenburger, Douglas A. (Contributor), Meyer, Aaron Samuel (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-12-28T12:59:46Z.
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