Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor

Optimizing bio-production involves strain and process improvements performed as discrete steps. However, environment impacts genotype and a strain that is optimal under one set of conditions may not be under different conditions. We present a methodology to simultaneously vary genetic and process fa...

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Bibliographic Details
Main Authors: Zhou, Hui (Contributor), Vonk, Brenda (Author), Roubos, Johannes A. (Author), Voigt, Christopher A. (Contributor), Bovenberg, Roel A. L. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor)
Format: Article
Language:English
Published: Oxford University Press, 2016-01-04T15:30:37Z.
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