Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

Background Viruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which natural killer (NK) cells recognize HIV-1-infected cells and how this virus can evade NK-cell-mediated immune pressure. Methods and Fin...

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Main Authors: Thobakgale, Christina F. (Author), Jimenez Cruz, Camilo A. (Author), Garcia-Beltran, Wilfredo F. (Author), Carlson, Jonathan M. (Author), van Teijlingen, Nienke H. (Author), Mann, Jaclyn K. (Author), Jaggernath, Manjeetha (Author), Kang, Seung-gu (Author), Chung, Amy W. (Author), Schafer, Jamie L. (Author), Evans, David T. (Author), Alter, Galit (Contributor), Walker, Bruce D. (Author), Goulder, Philip J. (Author), Carrington, Mary (Author), Hartmann, Pia (Author), Pertel, Thomas (Author), Zhou, Ruhong (Author), Ndung'u, Thumbi (Author), Altfeld, Marcus (Author), Holzemer, Angelique (Author), Korner, Christian (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2016-01-05T01:24:51Z.
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