Extensive Variation in Chromatin States Across Humans

Extensive Variation in Chromatin States Across Humans

The majority of disease-associated variants lie outside protein-coding regions, suggesting a link between variation in regulatory regions and disease predisposition. We studied differences in chromatin states using five histone modifications, cohesin, and CTCF in lymphoblastoid lines from 19 individ...

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Main Authors: Kasowski, Maya (Author), Kyriazopoulou-Panagiotopoulou, Sofia (Author), Grubert, Fabian (Author), Zaugg, Judith B. (Author), Kundaje, Anshul (Contributor), Liu, Yuling (Author), Boyle, Alan P. (Author), Zhang, Qiangfeng Cliff (Author), Zakharia, Fouad (Author), Spacek, Damek V. (Author), Li, Jingjing (Author), Xie, Dan (Author), Olarerin-George, Anthony (Author), Steinmetz, Lars M. (Author), Hogenesch, John B. (Author), Kellis, Manolis (Contributor), Batzoglou, Serafim (Author), Snyder, Michael (Author)
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2016-01-06T17:06:53Z.
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