BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability. Here, we show that BRCA1 is recruited to R-loops that form normally...

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Bibliographic Details
Main Authors: Hatchi, Elodie (Author), Skourti-Stathaki, Konstantina (Author), Ventz, Steffen (Author), Pinello, Luca (Author), Yen, Angela (Contributor), Kamieniarz-Gdula, Kinga (Author), Dimitrov, Stoil (Author), Pathania, Shailja (Author), McKinney, Kristine M (Author), Kellis, Manolis (Contributor), Hill, Sarah J (Author), Parmigiani, Giovanni (Author), Proudfoot, Nicholas J (Author), Livingston, David M (Author), Eaton, Matthew Lucas (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-01-10T20:19:09Z.
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