Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

Little is known about how mitotic cells round against epithelial confinement. Here, we engineer micropillar arrays that subject cells to lateral mechanical confinement similar to that experienced in epithelia. If generating sufficient force to deform the pillars, rounding epithelial (MDCK) cells can...

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Main Authors: Sorce, Barbara (Author), Escobedo, Carlos (Author), Toyoda, Yusuke (Author), Cattin, Cedric J. (Author), Newton, Richard (Author), Banerjee, Indranil (Author), Stettler, Alexander (Author), Roska, Botond (Author), Eaton, Suzanne (Author), Hyman, Anthony A. (Author), Hierlemann, Andreas (Author), Muller, Daniel J. (Author), Stewart, Martin P (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Stewart, Martin P. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-01-14T01:14:21Z.
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