Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

Studies of human genetics and pathophysiology have implicated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. These findings have motivated the use of small-molecule probes to study how modulation of autophagy affects disease-associated phenotypes. Here,...

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Main Authors: Kuo, Szu-Yu (Author), Castoreno, Adam B. (Author), Aldrich, Leslie N. (Author), Lassen, Kara G. (Author), Goel, Gautam (Author), Dancik, Vlado (Author), Kuballa, Petric (Author), Latorre, Isabel (Author), Conway, Kara L. (Author), Sarkar, Sovan (Author), Maetzel, Dorothea (Author), Jaenisch, Rudolf (Contributor), Clemons, Paul A. (Author), Schreiber, Stuart L. (Author), Shamji, Alykhan F. (Author), Xavier, Ramnik J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2016-02-05T12:57:03Z.
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