Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.

Bibliographic Details
Main Authors: Dong, Yizhou (Contributor), Eltoukhy, Ahmed A. (Contributor), Alabi, Christopher A. (Contributor), Veiseh, Omid (Contributor), Sirirungruang, Sasilada (Contributor), Yin, Hao (Contributor), Tang, Benjamin C. (Contributor), Chen, Delai (Contributor), Gu, Zhen (Contributor), Xue, Yuan (Contributor), Anderson, Daniel Griffith (Contributor), Pelet, Jeisa (Author), Langer, Robert S (Author), Khan, Omar Fizal (Author), Dorkin, Joseph Robert (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Khan, Omar F. (Contributor), Dorkin, J. Robert (Contributor), Pelet, Jeisa M. (Contributor), Langer, Robert (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2016-02-09T16:06:51Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items