Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design

Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design

A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic gripping sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral sequence variability among strains. Systematic means to guide immunogen design for highly variable pathogens like HIV a...

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Bibliographic Details
Main Authors: Ferguson, Andrew L (Author), Mann, Jaclyn K. (Author), Omarjee, Saleha (Author), Ndung'u, Thumbi (Author), Walker, Bruce D (Author), Chakraborty, Arup K (Author), Ferguson, Andrew L. (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Chakraborty, Arup K. (Contributor)
Format: Article
Language:English
Published: Elsevier/Cell Press, 2016-02-11T01:51:36Z.
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