Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design
A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic gripping sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral sequence variability among strains. Systematic means to guide immunogen design for highly variable pathogens like HIV a...
Main Authors: | , , , , , , |
---|---|
Other Authors: | , , , , |
Format: | Article |
Language: | English |
Published: |
Elsevier/Cell Press,
2016-02-11T01:51:36Z.
|
Subjects: | |
Online Access: | Get fulltext |