A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

Genital Chlamydia trachomatis (Ct) infection induces protective immunity that depends on interferon-γ-producing CD4 T cells. By contrast, we report that mucosal exposure to ultraviolet light (UV)-inactivated Ct (UV-Ct) generated regulatory T cells that exacerbated subsequent Ct infection. We show th...

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Bibliographic Details
Main Authors: Stary, George (Author), Olive, Andrew J. (Author), Radovic-Moreno, Aleksandar F. (Contributor), Gondek, David (Author), Alvarez, David (Author), Basto, Pamela A. (Contributor), Perro, Mario (Author), Vrbanac, Vladimir D. (Author), Tager, Andrew M. (Author), Shi, Jinjun (Author), Yethon, Jeremy A. (Author), Farokhzad, Omid C. (Author), Langer, Robert (Contributor), Starnbach, Michael N. (Author), von Andrian, Ulrich H. (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2016-02-17T21:52:11Z.
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