Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

To use microRNAs to downregulate mRNA targets, cells must first process these ∼22 nt RNAs from primary transcripts (pri-miRNAs). These transcripts form RNA hairpins important for processing, but additional determinants must distinguish pri-miRNAs from the many other hairpin-containing transcripts ex...

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Bibliographic Details
Main Authors: Auyeung, Vincent C (Author), Ulitsky, Igor (Contributor), McGeary, Sean Edward (Contributor), Bartel, David (Contributor), Auyeung, Vincent C. (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-02-24T16:46:37Z.
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