Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli

Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli

Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, with specificity regulated by the binding of an effector to a distal allosteric s...

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Main Authors: Kang, Gyung Hoon (Contributor), Chen, Yang-Ting (Author), Zimanyi, Christina Marie (Author), Funk, Michael Andrew (Author), Drennan, Catherine L (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Zimanyi, Christina M. (Contributor), Chen, Percival Yang-Ting (Contributor), Funk, Michael A. (Contributor), Drennan, Catherine L. (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd., 2016-03-02T02:46:35Z.
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