Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there first has to be an available pool of intracellular am...

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Main Authors: Carroll, Bernadette (Author), Maetzel, Dorothea (Author), Otten, Gisela (Author), Ratcliff, Matthew (Author), Jaenisch, Rudolf (Contributor), Sarkar, Sovan (Author), Maddocks, Oliver D. K. (Author), Smith, Graham R. (Author), Dunlop, Elaine A. (Author), Passos, Joao F. (Author), Davies, Owen R. (Author), Tee, Andrew R. (Author), Korolchuk, Viktor I. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd., 2016-03-03T00:47:54Z.
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