Molecular mechanism of force induced stabilization of collagen against enzymatic breakdown

Molecular mechanism of force induced stabilization of collagen against enzymatic breakdown

Collagen cleavage, facilitated by collagenases of the matrix metalloproteinase (MMP) family, is crucial for many physiological and pathological processes such as wound healing, tissue remodeling, cancer invasion and organ morphogenesis. Earlier work has shown that mechanical force alters the cleavag...

Full description

Bibliographic Details
Main Authors: Chang, Shu-Wei (Contributor), Flynn, Brendan P. (Author), Ruberti, Jeffrey W. (Author), Buehler, Markus J (Author)
Other Authors: Massachusetts Institute of Technology. Center for Materials Science and Engineering (Contributor), Massachusetts Institute of Technology. Center for Computational Engineering (Contributor), Massachusetts Institute of Technology. Department of Civil and Environmental Engineering (Contributor), Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics (Contributor), Buehler, Markus J. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-03-03T17:47:23Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items