Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

Understanding how antibiotics impact bacterial metabolism may provide insight into their mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we profiled the metabolome of Escherichia coli after treatment with three different classes of bactericidal antibiotics (β-lactams...

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Bibliographic Details
Main Authors: Belenky, Peter (Author), Ye, Jonathan D (Author), Cohen, Nadia R (Author), Ferrante, Thomas (Author), Jain, Saloni (Author), Korry, Benjamin J (Author), Schwarz, Eric G (Author), Walker, Graham C (Author), Collins, James J. (Contributor), Porter, Caroline (Contributor), Lobritz, Michael (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), MIT Synthetic Biology Center (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Cohen, Nadia R. (Contributor), Walker, Graham C. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-03-07T15:28:56Z.
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