Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

Cancer-associated fibroblasts (CAFs) are non-cancerous cells found in solid tumors that remodel the tumor matrix and promote cancer invasion and angiogenesis. Here, we demonstrate that Cdc42EP3/BORG2 is required for the matrix remodeling, invasion, angiogenesis, and tumor-growth-promoting abilities...

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Bibliographic Details
Main Authors: Calvo, Fernando (Author), Ranftl, Romana (Author), Hooper, Steven (Author), Farrugia, Aaron J (Author), Moeendarbary, Emad (Contributor), Bruckbauer, Andreas (Author), Batista, Facundo (Author), Charras, Guillaume (Author), Sahai, Erik (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-03-14T17:19:06Z.
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