Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression

Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression

Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here we show that FN gradients elicit directional movement of breast cancer cells, in vitro and in vivo. Haptotaxis on FN gradients requires direct interaction betwee...

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Main Authors: Oudin, Madeleine Julie (Contributor), Jonas, Oliver H. (Contributor), Kosciuk, Tatsiana (Contributor), Broye, Liliane C. (Contributor), Candido Guido, Bruna (Contributor), Wyckoff, Jeffrey (Contributor), Asokan, Sreeja B. (Author), Whittaker, Charles A. (Contributor), Ma, Duanduan (Contributor), Cima, Michael J. (Contributor), Wisinski, Kari B. (Author), Keely, Patricia J. (Author), Bear, James E. (Author), Gertler, Frank (Contributor), Riquelme, Daisy Noelia (Author), Lamar, John (Author), Langer, Robert S (Author), Hynes, Richard O (Author), Lauffenburger, Douglas A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Riquelme, Daisy (Contributor), Lamar, John Michael (Contributor), Langer, Robert (Contributor), Hynes, Richard O. (Contributor), Lauffenburger, Douglas A. (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2016-03-22T20:22:15Z.
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