Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

Lovastatin Corrects Excess Protein Synthesis and Prevents Epileptogenesis in a Mouse Model of Fragile X Syndrome

Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein synthesis...

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Bibliographic Details
Main Authors: Chuang, Shih-Chieh (Author), Chubykin, Alexander A (Author), Sidorov, Michael (Contributor), Bianchi, Riccardo (Author), Wong, Robert K.S (Author), Osterweil, Emily (Contributor), Bear, Mark (Contributor), Chubykin, Alexander A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-04-15T20:28:47Z.
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