Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Both intrinsic cell state changes and variations in the composition of stem cell populations have been implicated as contributors to aging. We used single-cell RNA-seq to dissect variability in hematopoietic stem cell (HSC) and hematopoietic progenitor cell populations from young and old mice from t...

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Bibliographic Details
Main Authors: Kowalczyk, Monika S. (Author), Tirosh, Itay (Author), Heckl, Dirk (Author), Rao, Tata Nageswara (Author), Dixit, Atray (Author), Haas, Brian J. (Author), Schneider, Rebekka K. (Author), Wagers, Amy J. (Author), Ebert, Benjamin L. (Author), Regev, Aviv (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2016-04-19T16:40:56Z.
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