Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
Both intrinsic cell state changes and variations in the composition of stem cell populations have been implicated as contributors to aging. We used single-cell RNA-seq to dissect variability in hematopoietic stem cell (HSC) and hematopoietic progenitor cell populations from young and old mice from t...
Main Authors: | Kowalczyk, Monika S. (Author), Tirosh, Itay (Author), Heckl, Dirk (Author), Rao, Tata Nageswara (Author), Dixit, Atray (Author), Haas, Brian J. (Author), Schneider, Rebekka K. (Author), Wagers, Amy J. (Author), Ebert, Benjamin L. (Author), Regev, Aviv (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor) |
Format: | Article |
Language: | English |
Published: |
Cold Spring Harbor Laboratory Press,
2016-04-19T16:40:56Z.
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Subjects: | |
Online Access: | Get fulltext |
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