Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic pla...

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Main Authors: Tian, Di (Contributor), Lindemann, Lothar (Author), Jaeschke, Georg (Author), Stoppel, Laura Jane (Contributor), Heynen, Arnold J. (Contributor), Mills, Alea A. (Author), Bear, Mark (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-04-29T17:00:04Z.
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