The Role of Cdk5 in Neuroendocrine Thyroid Cancer

The Role of Cdk5 in Neuroendocrine Thyroid Cancer

Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer that originates from calcitonin-secreting parafollicular cells, or C cells. We found that Cdk5 and its cofactors p35 and p25 are highly expressed in human MTC and that Cdk5 activity promotes MTC proliferation. A conditional MTC mouse model...

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Main Authors: Pozo, Karine (Author), Castro-Rivera, Emely (Author), Tan, Chunfeng (Author), Plattner, Florian (Author), Schwach, Gert (Author), Siegl, Veronika (Author), Meyer, Douglas (Author), Guo, Ailan (Author), Gundara, Justin (Author), Mettlach, Gabriel (Author), Richer, Edmond (Author), Guevara, Jonathan A (Author), Ning, Li (Author), Gupta, Anjali (Author), Hao, Guiyang (Author), Tsai, Li-Huei (Contributor), Sun, Xiankai (Author), Antich, Pietro (Author), Sidhu, Stanley (Author), Robinson, Bruce G (Author), Chen, Herbert (Author), Nwariaku, Fiemu E (Author), Pfragner, Roswitha (Author), Richardson, James A (Author), Bibb, James A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-05-16T16:50:47Z.
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