In vivo genome editing using Staphylococcus aureus Cas9

In vivo genome editing using Staphylococcus aureus Cas9

The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research and therapeutic applications that use the highly versatile adeno-associated virus (AAV) delivery...

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Main Authors: Ran, F. Ann (Author), Cong, Le (Contributor), Yan, Winston X. (Author), Gootenberg, Jonathan S. (Author), Kriz, Andrea J. (Contributor), Zetsche, Bernd (Author), Shalem, Ophir (Author), Wu, Xuebing (Contributor), Makarova, Kira S. (Author), Koonin, Eugene V. (Author), Sharp, Phillip A. (Contributor), Zhang, Feng (Contributor), Yan, Winston Xia (Contributor), Scott, David Arthur (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-05-23T00:19:06Z.
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