Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

While the affinities and specificities of SH2 domain-phosphotyrosine interactions have been well characterized, spatio-temporal changes in phosphosite availability in response to signals, and their impact on recruitment of SH2-containing proteins in vivo, are not well understood. To address this iss...

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Main Authors: Oh, Dongmyung (Author), Ogiue-Ikeda, Mari (Author), Machida, Kazuya (Author), Yu, Ji (Author), Jadwin, Joshua A. (Author), Curran, Timothy G. (Contributor), White, Forest M. (Contributor), Mayer, Bruce J. (Author), Jia, Lin, Ph. D. Massachusetts Institute of Technology (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd., 2016-05-23T15:38:50Z.
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